Naproxen 250mg/500mg + Domperidone 10mg is a combination medication used to relieve pain and reduce inflammation while minimizing gastrointestinal side effects. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting enzymes responsible for the production of prostaglandins, which are involved in pain, inflammation, and fever. It is effective in treating conditions like arthritis, muscle pain, dysmenorrhea, and gout. Domperidone, on the other hand, is a dopamine antagonist that increases gastric motility and prevents nausea and vomiting, which can be common side effects of NSAIDs. This combination is particularly useful in managing pain while preventing gastric discomfort or indigestion that NSAIDs might cause. It should be used with caution in individuals with renal or hepatic impairment and avoided in people with certain cardiac conditions.