Nimesulide 100mg. + Paracetamol 325mg. is a combination medication used for the relief of moderate pain and inflammation. Nimesulide, an NSAID, works by reducing inflammation and pain, while Paracetamol (Acetaminophen) is a pain reliever and fever reducer. This combination is commonly used for conditions such as arthritis, musculoskeletal pain, and mild to moderate headaches. The two active ingredients work synergistically, offering both anti-inflammatory and analgesic effects. While it provides effective relief, it should be used with caution, particularly in individuals with liver or kidney issues, as both Nimesulide and Paracetamol can have adverse effects on these organs when used long-term or in high doses.